This evening I loaded up a save and quickly found myself accosted by a particularly nasty monster, and I hit the space key to pause the game. The game did NOT pause, and I died without much incident. Further investigation revealed that all my hotkey settings had been wiped, and if I want them back I'll have to enter them in manually.

So I was wondering: 1) What the heck happened to my hotkeys?! and 2) Is there a way to reset them all at once to the default setting so I don't have to go through and do each manually?

1.45 patch, btw.