Does it still crash if you create a new profile, exit, copy your latest save to the new profile folder, restart the game and load the save without any mods enabled?
Try lowering the graphics settings and resolution, and switching to Windowed or Fake Fullscreen display mode, to see if that will make a difference.
In the Classic version of the game, a few people had crashes with certain skills (Tentacle Lash and Fire Whip) if the Virtual Memory setting in Windows was disabled or set to a fixed size, which could be avoided if it was set to automatic / system managed. That should be fixed in the Definitive Edition, and I don't recall the dwarf in the tavern using those skills, but it couldn't hurt to check. To check or change virtual memory settings in WIn 10:
http://www.tomshardware.com/faq/id-2864547/manage-virtual-memory-pagefile-windows.htmlPlease email supportdos2@larian.com with your save before a fight where this happens (or a Dropbox or Google drive link, etc). Also include a list of mods and/or the modsettings.lsx from your profile folder.
Each save is a folder in the '..\Documents\Larian Studios\Divinity Original Sin 2 Definitive Edition\PlayerProfiles\<ProfileName>\Savegames\Story' folder.
In Windows Explorer you can zip a file or folder by right clicking on it/them and selecting 'Send To | Compressed (zipped) Folder'.
In case the issue is not related to the save itself, include a dxdiag report (WinKey-R, type in dxdiag and hit enter, then when it finishes loading click on the 'Save All Information...' button and save the report somewhere handy); also check the '..\Divinity Original Sin 2\DefEd\bin' folder for the gold.log file, and if there are any 'CrashDump' files being created, zip a few together to include.